Publications

Stephens KK, Finnerty RM, Grant DG, Winuthayanon S, Martin-Deleon PA, Winuthayanon W. (2024) Proteomic analysis and in vivo visualization of extracellular vesicles from mouse oviducts during pre-implantation embryo development. FASEB J. 38:e70035 https://doi.org/10.1096/fj.202400041RR

Finnerty RM, Carulli DJ, Hedge A, Wang Y, Baodu F, Winuthayanon S, Cheng J, Winuthayanon W. (2024) Multi-omics analyses and machine learning prediction of oviductal responses in the presence of gametes and embryos. eLIFE. 13:RP100705. https://doi.org/10.7554/eLife.100705.1

Erickson JA, Jimmidi R, Anamthathmakula A, Qin X, Wang J, Gong L, Park J, Koolpe G, Tan C, Matzuk MM, Li F, Chamakuri S*, Winuthayanon W*. (2024) Synthesis and optimization of small molecule inhibitors of protease specific antigen. ACS Med Chem Lett. https://doi.org/10.1021/acsmedchemlett.4c00257 *co-corresponding authors

McGlade EA, Mao J, Stephens KK, Kelleher AM, Maddison LA, Bernhardt ML, DeMayo FJ, Lydon JP, Winuthayanon W. (2024) Generation of oviductal glycoprotein 1 Cre mouse model for the study of secretory epithelial cells of the oviduct. Endocrinology. 165:7 bqae070 https://doi.org/10.1210/endocr/bqae070 

Finnerty RM, Carulli EM, Bernhardt ML, Maddison LA, Winuthayanon W. (2024) Deletion of Kallikrein-related peptidases (Klks) has no effect on fertility in mice. microPublication Biology. 001070. https://doi.org/10.17912/micropub.biology.001070

McGlade EA, Stephens KK, Winuthayanon S, Anamthathmakula A, Holtzman MJ, Winuthayanon W. (2024) Classical estrogen signaling in ciliated epithelial cells of the oviduct is nonessential for fertility in female mice. Endocrinology. 165: bqad163 https://doi.org/10.1210/endocr/bqad163

Rizo JA, Davenport KM, Winuthayanon W, Spencer TE, Kelleher AM. (2023) Estrogen receptor alpha regulates uterine epithelial lineage specification and homeostasis. iScience. 26: 107568. https://doi.org/10.1016/j.isci.2023.107568

Anamthathmakula P, Erickson JA, and Winuthayanon W. (2022) Blocking serine protease activity prevents semenogelin degradation leading to hyperviscous semen in humans. Biol Reprod. ioac023. https://doi.org/10.1093/biolre/ioac023

McGlade EA, Herrera GG, Stephens KK, Olsen SLW, Winuthayanon S, Guner J, Hewitt SC, Korach KS, DeMayo FJ, Lydon JP, Monsivais D, and Winuthayanon W. (2021) Cell-type specific analysis of physiological action of estrogen in mouse oviducts. FASEB J. 35;e21563; 1-19. https://doi.org/10.1093/biolre/ioac023

Hewitt SC, Carmona M, Foley G, Donoghue LJ, Lierz SL, Winuthayanon W, and Korach KS. (2020) Peri- and post-pubertal estrogen exposures of female mice optimize uterine responses later in life. Endocrinology. 161(8):1-12. https://doi.org/10.1210/endocr/bqaa081

Barton BE, Rock JK, Willie AM, Harris EA, Finnerty RM, Herrera GG, Anamthathmakula P, and Winuthayanon W. (2020) Serine protease inhibitor disrupts sperm motility leading to reduced fertility in female mice. Biol Reprod. 103:400-410. https://doi.org/10.1093/biolre/ioaa049

Griffiths RM, Pru CA, Behura SK, Cronrath AR, McCallum ML, Kelp NC, Winuthayanon W, Spencer TE, and Pru JK. (2020) AMPK is required for uterine receptivity and normal responses to steroid hormones. Reproduction. 159:707-717. https://doi.org/10.1530/REP-19-0402

Herrera GG, Lierz SL, Harris EA, Donoghue LJ, Hewitt SC, Rodriguez KF, Jefferson WN, Lydon JP, DeMayo FJ, Williams CJ, Korach KS, and Winuthayanon W. (2020) Oviductal Retention of Embryos in Female Mice Lacking Estrogen Receptor α in the Isthmus and the Uterus. Endocrinology. 161(2):1-12. https://doi.org/10.1210/endocr/bqz033

Li S, Beedle MT, Herrera GB, Tam KT, and Winuthayanon W. (2019) Deletion of kallikrein 1b5 (Klk1b5) has no impact on fertility in mice. Mol Reprod & Dev. DOI: 10.1002/mrd.23145. https://doi.org/10.1002/mrd.23145 

Hewitt SC, Li R, Adams N, Winuthayanon W, Hamilton KJ, Donoghue LJ, Lierz SL, Garcia M, Lydon JP, DeMayo FJ Adelman K, and Korach KS. (2018) Negative elongation factor is essential for endometrial function. FASEB J. 33(2): 3010-3023. https://doi.org/10.1096/fj.201801752

Li S, Herrera GG, Tam KK, Lizarraga JS, Beedle M-T, Winuthayanon W. (2018) Estrogen Action in the Epithelial Cells of the Mouse Vagina Regulates Neutrophil Infiltration and Vaginal Tissue Integrity. Sci Rep. 8(11247): 1-13. https://doi.org/10.1038/s41598-018-29423-5

Siller SS, Sharma H, Li S, Holtzman MJ, Winuthayanon W, Colognato H, Holdener B, Li F-Q, and Takemaru K-I. (2017) Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway ciliogenesis. PLoS Genetics. 13: e1007128. https://doi.org/10.1371/journal.pgen.1007128

Li S and Winuthayanon W (2017) Collection of Post-Mating Semen from the Female Reproductive Tract and Measurement of Semen Liquefaction in Mice. J Vis Exp. 129: e56670. video link. https://doi.org/10.3791/56670

Winuthayanon W*, Lierz SL, Delarosa KC, Sampels SR, Donoghue LJ, Hewitt SC, and Korach KS (2017). Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation. Sci Rep. 7(8377):1-15. *corresponding author. Post-publication peer reviewed recognition in F1000 as “Very Good”, Sep 2017. https://doi.org/10.1038/s41598-017-07728-1

Li S, Garcia M, Gewiss RL, Winuthayanon W. (2017) Crucial Role of Estrogen for the Mammalian Female in Regulating Semen Coagulation and Liquefaction in Vivo. PLoS Genetics. 13: e1006743. Featured in news outlets (sciencedaily, medicalnewstoday, phys.org, and WSU news) https://doi.org/10.1371/journal.pgen.1006743

Li S, O’Neill SRS, Zhang Y, Holtzman MJ, Takemaru K-I, Korach KS, and Winuthayanon W. (2017). Estrogen receptor α is required for oviductal transport of embryos. FASEB J. 31: 1595-1607. https://doi.org/10.1096/fj.201601128R

Hewitt SC, Winuthayanon W, Lierz SL, Hamilton KJ, Donoghue LJ, Ramsey JT, Grimm SA, Arao Y, Korach KS. (2017) Role of ERα in Mediating Female Uterine Transcriptional Responses to IGF1. Endocrinology. 158: 2427-2435. https://doi.org/10.1210/en.2017-00349

Thongon N, Boonmuen N, Suksen K, Wichit P, Chiroungdua A, Tuchinda P, Suksamrarn A, Winuthayanon W, Piyachaturawat P. (2017) Selective estrogen receptor modulator (SERM)-like activities of diarylheptanoid, a phytoestrogen from Curcuma comosa, in breast cancer cells, pre-osteoblast cells, and rat uterine tissues. J Agric Food Chem. 65: 3490-3496. https://doi.org/10.1021/acs.jafc.7b00769

Winuthayanon W*, Bernhardt ML, Padilla-Banks E, Myers PH, Edin ML, Lih F, Korach KS, and Williams CJ*. (2015) Oviductal estrogen receptor α signaling prevents protease-mediated embryo death. eLIFE. 4: e10453. *Co-corresponding authors. NIEHS Paper of the month, Dec 2015. Highlighted in World of Reproductive Biology: The Inconstant Oviduct, Dec 2015. https://doi.org/10.7554/eLife.10453

Hewitt SC, Winuthayanon W, Pockette B, Kerns RT, Suksamrarn A, Piyachaturawat P, Bushel PR, Korach KS. (2015) Development of phenotypic and transcriptional biomarkers to establish activity and potency of candidate xenoextrogens. Environ Health Perspect. 123: 334-52. https://doi.org/10.1289/ehp.1307935

Winuthayanon W, Hewitt SC, and Korach KS. (2014) Uterine epithelial cell ERα –dependent and –independent genomic profiles that underlie estrogen response. Biol Reprod. 95: 1-10. NIEHS paper of the month, Feb 2015. https://doi.org/10.1095/biolreprod.114.120170

Winuthayanon W, Piyachaturawat P, Suksamrarn A, Arao Y, Burns KA, Hewitt SC, Pedersen LC, and Korach KS. (2013) Natural Estrogenic Compound Diarylheptanoid (D3): In vitro Mechanisms of Action and In Vivo Uterine Responses via Estrogen Receptor α. Environ Health Perspect. 121:433-9. NIEHS paper of the month, Jun 2013. https://doi.org/10.1289/ehp.1206122

Winuthayanon W, Hewitt SC, Orvis GD, Behringer RR, and Korach KS. (2010) Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses. Proc Natl Acad Sci USA. 107: 19272-7. Post-publication peer reviewed recognition in F1000 as “must read paper”, Nov 2010, NIEHS paper of the month, Jan 2011. https://doi.org/10.1073/pnas.1013226107

Winuthayanon W, Piyachaturawat P, Suksamrarn A, Ponglikitmongkol M, Arao Y, Hewitt SC, and Korach KS. (2009) Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms. Environ Health Perspect. 117: 1155-61. https://ehp.niehs.nih.gov/doi/full/10.1289/ehp.0900613

Winuthayanon W, Suksen K, Boonchird C, Chuncharunee A, Ponglikitmongkol M, Suksamrarn A, Piyachaturawat P. (2009) Estrogenic activity of diarylheptanoids from Curcuma comosa Roxb. requires metabolic activation. J Agric Food Chem. 57: 840-5. https://doi.org/10.1021/jf802702c

Hunter MI, Thies KM, Winuthayanon W. (2024) Hormonal regulation of cilia in the female reproductive tract. Current Opinion in Endocrine and Metabolic Research. 100503. https://doi.org/10.1016/j.coemr.2024.100503

Barton BE, Erickson JA, Allred SI, Jeffries JM, Stephens KK, Hunter MI, Woodall KA, Winuthayanon W. (2024) Reversible female contraceptives: historical, current, and future perspectives. Biol Reprod. ioad154. https://doi.org/10.1093/biolre/ioad154

McGlade EA, Miyamoto A, and Winuthayanon W. (2022) Progesterone and inflammatory response in the oviduct during physiological and pathological conditions. Cells. 11(7): 1075. https://doi.org/10.3390/cells11071075

Anamthathmakula P and Winuthayanon W. (2021) Prostaglandin-endoperoxide synthase 2 (PTGS2) in the oviduct: roles in fertilization and early embryo development. Endocrinology. 162: 1-14. https://doi.org/10.1210/endocr/bqab025

Harris EA, Stephens KK, and Winuthayanon W. (2020) Extracellular Vesicles and the Oviduct Function. Intl J Mol Sci. 21: 8280 (p1-20). https://doi.org/10.3390/ijms21218280

Anamthathmakula P and Winuthayanon W. (2020) Mechanism of semen liquefaction and its potential for a novel non-Hormonal contraception. Biol Reprod. 103: 411-426. https://doi.org/10.1093/biolre/ioaa075

Barton BE, Herrera GG, Anamthathmakula P, Rock JK, Willie AM, Harris HA, Takemaru K-I, and Winuthayanon W. (2020) Roles of steroid hormones in oviduct function. Reproduction. 159: R125-R137. https://doi.org/10.1530/REP-19-0189

Li S and Winuthayanon W. (2017) Oviduct: Roles in Fertilization and Early Embryo Development. J Endocrin. 232: R1-26. https://doi.org/10.1530/JOE-16-0302

Hewitt SC, Winuthayanon W, and Korach KS. (2016) What’s new in estrogen receptor action in the female reproductive tract. J Mol Endocrin. 56: R55-71. https://doi.org/10.1530/JME-15-0254

Mao J, Finnerty RM, Brennaman LM, Theis KM, Hunter MI, and Winuthayanon W. (2024) Fallopian Tube/Oviduct: Structure and Cell Biology. In: MK Skinner (ed.), Encyclopedia of Reproduction, vol. 2, 3rd ed. Academic Press, London: Elsevier. In press.

 Mahalingam S, Finnerty RM, and Winuthayanon W. (2024) Embryo Transport. In: MK Skinner (ed.), Encyclopedia of Reproduction, vol. 3, 3rd ed. Academic Press, London: Elsevier. In press.

Winuthayanon W and Li S. (2018) Fallopian Tube/Oviduct: Structure and Cell Biology. In: MK Skinner (ed.), Encyclopedia of Reproduction, vol. 2, 2nd ed. Academic Press, London: Elsevier. pp282-290. https://doi.org/10.1016/B978-0-12-801238-3.64401-X

Olsen, LW, Li S, Winuthayanon W. (2018) Embryo Transport. In: MK Skinner (ed.), Encyclopedia of Reproduction, vol. 3, 2nd ed. Academic Press, London: Elsevier. pp357–363. https://doi.org/10.1016/B978-0-12-801238-3.64489-6

Binder AK, Winuthayanon W, Hewitt SC, Couse JF, and Korach, KS. (2015) Steroid Receptors in the Ovary and Uterus. In: Plant TM and Zeleznik AJ (eds.), Knobil and Neill’s Physiology of Reproduction, vol. 1, 4th ed. London: Elsevier; 1099-1193. https://doi.org/10.1016/B978-0-12-397175-3.00025-9

Deroo BJ, Burns KA, Winuthayanon W, and Korach, KS. (2009) Potential effects for environmental xeno-oestrogens: Pollution and fertility. The Biochemist. 31(2):22-26. https://doi.org/10.1042/BIO03102022